※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Muf-0032	ENSMPUG00000000860.1	M3XP56
2		iEKPD-Muf-0033	ENSMPUG00000000863.1	M3XP59
3		iEKPD-Muf-0270	ENSMPUG00000011015.1	M3YHW9
4		iEKPD-Muf-0138	ENSMPUG00000005495.1	M3Y2A3	ILK
5		iEKPD-Muf-0440	ENSMPUG00000017712.1	M3Z1Y9	MAP3K10
6		iEKPD-Muf-0286	ENSMPUG00000011832.1	M3YK81	MAP3K11
7		iEKPD-Muf-0147	ENSMPUG00000005953.1	M3Y3K1	MAP3K12
8		iEKPD-Muf-0142	ENSMPUG00000005751.1	M3Y303	MAP3K21
9		iEKPD-Muf-0231	ENSMPUG00000009090.1	M3YCF7	MAP3K7
10		iEKPD-Muf-0095	ENSMPUG00000003616.1	M3XWY7	MAP3K9