※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Myl-0436	ENSMLUG00000023950.1	G1QCG5
2		iEKPD-Myl-0207	ENSMLUG00000008954.2	G1PCN1	ILK
3		iEKPD-Myl-0134	ENSMLUG00000005964.2	G1P5Z8	LOC102425104
4		iEKPD-Myl-0386	ENSMLUG00000016366.2	G1QAN8	MAP3K10
5		iEKPD-Myl-0199	ENSMLUG00000008611.2	G1PBV3	MAP3K11
6		iEKPD-Myl-0230	ENSMLUG00000010002.2	G1PF07	MAP3K12
7		iEKPD-Myl-0107	ENSMLUG00000004734.2	G1P337	MAP3K13
8		iEKPD-Myl-0149	ENSMLUG00000006601.2	G1P7E8	MAP3K20
9		iEKPD-Myl-0078	ENSMLUG00000003344.2	G1NZX8	MAP3K7
10		iEKPD-Myl-0408	ENSMLUG00000017361.2	G1PWP4	MAP3K9