※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Nol-0231	ENSNLEG00000009478.3	G1RED3
2		iEKPD-Nol-0333	ENSNLEG00000014086.3	G1RV36
3		iEKPD-Nol-0421	ENSNLEG00000017450.2	A0A2I3HF70	ILK
4		iEKPD-Nol-0154	ENSNLEG00000005717.3	G1R178	MAP3K11
5		iEKPD-Nol-0429	ENSNLEG00000017692.2	G1S7H7	MAP3K12
6		iEKPD-Nol-0165	ENSNLEG00000006452.2	G1R3U1	MAP3K13
7		iEKPD-Nol-0155	ENSNLEG00000005760.2	A0A2I3FR90	MAP3K20
8		iEKPD-Nol-0071	ENSNLEG00000002463.3	G1QPW4	MAP3K21
9		iEKPD-Nol-0314	ENSNLEG00000013337.3	G1RSQ0	MAP3K7
10		iEKPD-Nol-0050	ENSNLEG00000001891.3	G1QMU3	MAP3K9