※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ora-0004	ENSOANG00000000297.1	F6TFS4
2		iEKPD-Ora-0055	ENSOANG00000002466.3	F6WAZ2
3		iEKPD-Ora-0389	ENSOANG00000019900.2	F7CEU4
4		iEKPD-Ora-0401	ENSOANG00000020838.2	F7ETK2
5		iEKPD-Ora-0404	ENSOANG00000021057.2	F7EAV3
6		iEKPD-Ora-0351	ENSOANG00000014531.2	F6UHX1	LOC100076986
7		iEKPD-Ora-0468	ENSOANG00000030986.1	K7EDP8	LOC100082192
8		iEKPD-Ora-0199	ENSOANG00000008595.2	F7CBA7	MAP3K20
9		iEKPD-Ora-0205	ENSOANG00000008928.2	F7D2W4	MAP3K7