※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Orc-0058	ENSOCUG00000003001.3	G1SIU1
2		iEKPD-Orc-0127	ENSOCUG00000006593.2	G1SRA9	ILK
3		iEKPD-Orc-0284	ENSOCUG00000013657.3	G1T5V4	MAP3K10
4		iEKPD-Orc-0277	ENSOCUG00000013282.3	G1T535	MAP3K11
5		iEKPD-Orc-0112	ENSOCUG00000005689.2	G1SPG5	MAP3K12
6		iEKPD-Orc-0317	ENSOCUG00000015053.2	G1T8M6	MAP3K20
7		iEKPD-Orc-0211	ENSOCUG00000010372.3	G1SZ61	MAP3K21
8		iEKPD-Orc-0028	ENSOCUG00000001698.2	G1SFY3	MAP3K7
9		iEKPD-Orc-0064	ENSOCUG00000003204.3	G1SJ83	MAP3K9