※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Osl-0045	OSTLU_3085	A4S4H8	OSTLU_3085
2		iEKPD-Osl-0063	OSTLU_3629	A4S7Z1	OSTLU_3629
3		iEKPD-Osl-0074	OSTLU_38832	A4RXR3	OSTLU_38832
4		iEKPD-Osl-0095	OSTLU_42011	A4S9V5	OSTLU_42011
5		iEKPD-Osl-0103	OSTLU_45682	A4RXI8	OSTLU_45682
6		iEKPD-Osl-0104	OSTLU_46664	A4S2A1	OSTLU_46664
7		iEKPD-Osl-0114	OSTLU_5051	A4S4W8	OSTLU_5051
8		iEKPD-Osl-0117	OSTLU_50798	A4S4M0	OSTLU_50798
9		iEKPD-Osl-0119	OSTLU_6189	A4SBG1	OSTLU_6189
10		iEKPD-Osl-0123	OSTLU_7730	A4RXJ0	OSTLU_7730
11		iEKPD-Osl-0129	OSTLU_87238	A4RXB2	OSTLU_87238