※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Otg-0274	ENSOGAG00000011573.2	H0X533
2		iEKPD-Otg-0157	ENSOGAG00000007187.2	H0WVT1	ILK
3		iEKPD-Otg-0333	ENSOGAG00000014054.2	H0XAF1	LOC100943238
4		iEKPD-Otg-0330	ENSOGAG00000013974.2	H0XA78	MAP3K10
5		iEKPD-Otg-0334	ENSOGAG00000014085.2	H0XAI1	MAP3K11
6		iEKPD-Otg-0036	ENSOGAG00000001739.2	H0WJ90	MAP3K12
7		iEKPD-Otg-0338	ENSOGAG00000014223.2	H0XAT1	MAP3K13
8		iEKPD-Otg-0236	ENSOGAG00000010128.2	H0X204	MAP3K21
9		iEKPD-Otg-0137	ENSOGAG00000006039.2	H0WTC8	MAP3K7
10		iEKPD-Otg-0264	ENSOGAG00000011147.2	H0X470	MAP3K9