※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ova-0391	ENSOARG00000017258.1	W5Q731	ILK
2		iEKPD-Ova-0275	ENSOARG00000012319.1	W5PRX3	LOC101120030
3		iEKPD-Ova-0148	ENSOARG00000006462.1	W5P908	MAP3K10
4		iEKPD-Ova-0374	ENSOARG00000016243.1	W5Q401	MAP3K11
5		iEKPD-Ova-0376	ENSOARG00000016453.1	W5Q4M9	MAP3K12
6		iEKPD-Ova-0464	ENSOARG00000020566.1	W5QHA1	MAP3K13
7		iEKPD-Ova-0015	ENSOARG00000000725.1	W5NRF7	MAP3K20
8		iEKPD-Ova-0075	ENSOARG00000003390.1	W5NZM3	MAP3K21
9		iEKPD-Ova-0276	ENSOARG00000012321.1	W5PRX8	MAP3K7
10		iEKPD-Ova-0481	ENSOARG00000021197.1	W5QJ82	MAP3K9