※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Paa-0350	ENSPANG00000022216.2	A0A2I3NAN3
2		iEKPD-Paa-0399	ENSPANG00000023648.2	A0A096NE53	ILK
3		iEKPD-Paa-0215	ENSPANG00000016117.2	A0A0A0MV36	MAP3K10
4		iEKPD-Paa-0075	ENSPANG00000006544.2	A0A096N4Z8	MAP3K11
5		iEKPD-Paa-0312	ENSPANG00000020580.2	A0A2I3MII1	MAP3K12
6		iEKPD-Paa-0285	ENSPANG00000019213.2	A0A096N782	MAP3K13
7		iEKPD-Paa-0001	ENSPANG00000000071.3	A0A096NZL7	MAP3K20
8		iEKPD-Paa-0178	ENSPANG00000013610.2	A0A2I3N433	MAP3K21
9		iEKPD-Paa-0344	ENSPANG00000021959.2	A0A2I3LYE7	MAP3K7
10		iEKPD-Paa-0405	ENSPANG00000024112.2	A0A2I3LNV8	MAP3K9