※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Poa-0002	ENSPPYG00000000106.2	H2N3D7
2		iEKPD-Poa-0029	ENSPPYG00000001237.2	H2N716
3		iEKPD-Poa-0075	ENSPPYG00000003537.2	H2NE91	ILK
4		iEKPD-Poa-0216	ENSPPYG00000009985.2	H2NYU5	MAP3K10
5		iEKPD-Poa-0066	ENSPPYG00000003058.2	H2NCV2	MAP3K11
6		iEKPD-Poa-0090	ENSPPYG00000004582.2	H2NHH3	MAP3K12
7		iEKPD-Poa-0315	ENSPPYG00000014365.2	H2PC81	MAP3K13
8		iEKPD-Poa-0277	ENSPPYG00000012939.2	H2P7U9	MAP3K20
9		iEKPD-Poa-0371	ENSPPYG00000016850.2	H2PJU2	MAP3K7
10		iEKPD-Poa-0123	ENSPPYG00000005956.1	H2NLP2	MAP3K9