※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sem-1144	SELMODRAFT_97070
2		iEKPD-Sem-0037	SELMODRAFT_10499	D8SYB4	CTR1L1-1
3		iEKPD-Sem-0682	SELMODRAFT_40986	D8T748	CTR1L1-2
4		iEKPD-Sem-0853	SELMODRAFT_443349	D8S0M2	MAP3K
5		iEKPD-Sem-0042	SELMODRAFT_105905	D8S0G7	SELMODRAFT_105905
6		iEKPD-Sem-1023	SELMODRAFT_78499	D8QW66	SELMODRAFT_112293
7		iEKPD-Sem-1099	SELMODRAFT_88196	D8R9N6	SELMODRAFT_115084
8		iEKPD-Sem-0128	SELMODRAFT_115356	D8SEQ6	SELMODRAFT_115356
9		iEKPD-Sem-0136	SELMODRAFT_117219	D8SHP2	SELMODRAFT_117219
10		iEKPD-Sem-0137	SELMODRAFT_117402	D8SI90	SELMODRAFT_117402
11		iEKPD-Sem-0138	SELMODRAFT_117448	D8SID3	SELMODRAFT_117448
12		iEKPD-Sem-0144	SELMODRAFT_118910	D8SKB3	SELMODRAFT_118910
13		iEKPD-Sem-0216	SELMODRAFT_130298	D8T298	SELMODRAFT_130298
14		iEKPD-Sem-0228	SELMODRAFT_131553	D8T4D8	SELMODRAFT_131553
15		iEKPD-Sem-0303	SELMODRAFT_14347	D8S6T7	SELMODRAFT_14347
16		iEKPD-Sem-0313	SELMODRAFT_146775	D8RFU9	SELMODRAFT_146775
17		iEKPD-Sem-0314	SELMODRAFT_146897	D8RG80	SELMODRAFT_146897
18		iEKPD-Sem-0949	SELMODRAFT_57136	D8SGM9	SELMODRAFT_155162
19		iEKPD-Sem-0337	SELMODRAFT_157107	D8SPA3	SELMODRAFT_157107
20		iEKPD-Sem-0345	SELMODRAFT_160379	D8T2B4	SELMODRAFT_160379
21		iEKPD-Sem-0347	SELMODRAFT_161918	D8T850	SELMODRAFT_161918
22		iEKPD-Sem-0403	SELMODRAFT_174753	D8RVV4	SELMODRAFT_174753
23		iEKPD-Sem-0427	SELMODRAFT_177674	D8S7W1	SELMODRAFT_177674
24		iEKPD-Sem-0442	SELMODRAFT_184879	D8T2S8	SELMODRAFT_184879
25		iEKPD-Sem-0453	SELMODRAFT_186310	D8T836	SELMODRAFT_186310
26		iEKPD-Sem-0462	SELMODRAFT_20996	D8R337	SELMODRAFT_20996
27		iEKPD-Sem-0489	SELMODRAFT_234257	D8SJC0	SELMODRAFT_234257
28		iEKPD-Sem-0504	SELMODRAFT_23730	D8T0C9	SELMODRAFT_23730
29		iEKPD-Sem-0542	SELMODRAFT_269874	D8T8P2	SELMODRAFT_269874
30		iEKPD-Sem-0544	SELMODRAFT_271276	D8S3C7	SELMODRAFT_271276
31		iEKPD-Sem-0546	SELMODRAFT_27259	D8QUN9	SELMODRAFT_27259
32		iEKPD-Sem-0559	SELMODRAFT_27762	D8QUP0	SELMODRAFT_27762
33		iEKPD-Sem-0586	SELMODRAFT_3146	D8T7A2	SELMODRAFT_3146
34		iEKPD-Sem-0596	SELMODRAFT_34528	D8QYG2	SELMODRAFT_34528
35		iEKPD-Sem-0609	SELMODRAFT_37312	D8RXD0	SELMODRAFT_37312
36		iEKPD-Sem-0610	SELMODRAFT_37511	D8RGZ9	SELMODRAFT_37511
37		iEKPD-Sem-0647	SELMODRAFT_40493	D8SQG3	SELMODRAFT_40493
38		iEKPD-Sem-0680	SELMODRAFT_409667	D8RC21	SELMODRAFT_409667
39		iEKPD-Sem-0705	SELMODRAFT_414266	D8RS71	SELMODRAFT_414266
40		iEKPD-Sem-0714	SELMODRAFT_415644	D8RWS8	SELMODRAFT_415644
41		iEKPD-Sem-0749	SELMODRAFT_422047	D8SH64	SELMODRAFT_422047
42		iEKPD-Sem-0752	SELMODRAFT_422414	D8SIB5	SELMODRAFT_422414
43		iEKPD-Sem-0795	SELMODRAFT_428198	D8T225	SELMODRAFT_428198
44		iEKPD-Sem-0797	SELMODRAFT_428456	D8T2W8	SELMODRAFT_428456
45		iEKPD-Sem-0815	SELMODRAFT_431592	D8TD54	SELMODRAFT_431592
46		iEKPD-Sem-0834	SELMODRAFT_43546	D8STW6	SELMODRAFT_43546
47		iEKPD-Sem-0864	SELMODRAFT_444789	D8SD04	SELMODRAFT_444789
48		iEKPD-Sem-0868	SELMODRAFT_446494	D8SRX6	SELMODRAFT_446494
49		iEKPD-Sem-0873	SELMODRAFT_449389	D8TG89	SELMODRAFT_449389
50		iEKPD-Sem-0893	SELMODRAFT_449530	D8SBA9	SELMODRAFT_449530
51		iEKPD-Sem-0923	SELMODRAFT_451542	D8R6D3	SELMODRAFT_451542
52		iEKPD-Sem-0966	SELMODRAFT_6434	D8T1E6	SELMODRAFT_6434
53		iEKPD-Sem-1120	SELMODRAFT_90847	D8RCG6	SELMODRAFT_90847
54		iEKPD-Sem-1132	SELMODRAFT_932	D8TF10	SELMODRAFT_932
55		iEKPD-Sem-0151	SELMODRAFT_120027	D8RMM2	SELMODRAFT_97070