※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sei-0568	Si016766m.g	K3YR72	LOC101752472
2		iEKPD-Sei-0506	Si016157m.g	K3YPG5	LOC101753714
3		iEKPD-Sei-1048	Si029452m.g	K3ZS72	LOC101753744
4		iEKPD-Sei-1003	Si029013m.g	K3ZQY3	LOC101754395
5		iEKPD-Sei-0536	Si016359m.g	K3YQ17	LOC101754501
6		iEKPD-Sei-0713	Si021511m.g	K3Z4P3	LOC101756326
7		iEKPD-Sei-0905	Si027523m.g	K3ZLR2	LOC101757926
8		iEKPD-Sei-0505	Si016154m.g	K3YPG2	LOC101759918
9		iEKPD-Sei-1035	Si029284m.g	K3ZRQ4	LOC101761030
10		iEKPD-Sei-0377	Si010212m.g	K3Y7M1	LOC101761558
11		iEKPD-Sei-0053	Si000557m.g	K3XF88	LOC101761902
12		iEKPD-Sei-1276	Si036191m.g	K4ABD4	LOC101762013
13		iEKPD-Sei-1160	Si034063m.g	K4A5A9	LOC101762982
14		iEKPD-Sei-1005	Si029030m.g	K3ZR00	LOC101765600
15		iEKPD-Sei-0079	Si000750m.g	K3XFT1	LOC101765837
16		iEKPD-Sei-0530	Si016301m.g	K3YPV9	LOC101765843
17		iEKPD-Sei-0036	Si000364m.g	K3XEP7	LOC101767740
18		iEKPD-Sei-1163	Si034087m.g	K4A5D3	LOC101767843
19		iEKPD-Sei-0207	Si005743m.g	K3XUY6	LOC101767850
20		iEKPD-Sei-0990	Si028893m.g	K3ZQL3	LOC101768206
21		iEKPD-Sei-0609	Si017658m.g	K3YTR1	LOC101768303
22		iEKPD-Sei-0964	Si028383m.g	K3ZP53	LOC101768892
23		iEKPD-Sei-0800	Si024868m.g	K3ZE75	LOC101769300
24		iEKPD-Sei-0105	Si001285m.g	K3XHB4	LOC101769908
25		iEKPD-Sei-0580	Si017053m.g	K3YS09	LOC101770735
26		iEKPD-Sei-0533	Si016333m.g	K3YPZ1	LOC101772325
27		iEKPD-Sei-0760	Si022280m.g	K3Z6W1	LOC101772387
28		iEKPD-Sei-0766	Si022425m.g	K3Z7A5	LOC101773771
29		iEKPD-Sei-0865	Si026243m.g	K3ZI41	LOC101775364
30		iEKPD-Sei-1062	Si029825m.g	K3ZT95	LOC101775475
31		iEKPD-Sei-0293	Si008355m.g	K3Y2D2	LOC101775535
32		iEKPD-Sei-1843	Si013254m.g	K3YG86	LOC101776261
33		iEKPD-Sei-0716	Si021527m.g	K3Z4Q9	LOC101777133
34		iEKPD-Sei-0460	Si013509m.g	K3YGZ1	LOC101777899
35		iEKPD-Sei-1266	Si035834m.g	K4AAC7	LOC101777977
36		iEKPD-Sei-0860	Si026192m.g	K3ZHZ0	LOC101778086
37		iEKPD-Sei-1240	Si035264m.g	K4A8Q8	LOC101778934
38		iEKPD-Sei-1270	Si035970m.g	K4AAR3	LOC101779047
39		iEKPD-Sei-0127	Si001833m.g	K3XIW0	LOC101779225
40		iEKPD-Sei-0364	Si009795m.g	K3Y6F4	LOC101780071
41		iEKPD-Sei-1225	Si034839m.g	K4A7I3	LOC101780135
42		iEKPD-Sei-0050	Si000543m.g	K3XF74	LOC101780302
43		iEKPD-Sei-0128	Si001885m.g	K3XJ12	LOC101780699
44		iEKPD-Sei-0080	Si000760m.g	K3XFU1	LOC101780956
45		iEKPD-Sei-0594	Si017293m.g	K3YSQ2	LOC101781630
46		iEKPD-Sei-1309	Si039007m.g	K4AJE0	LOC101782005
47		iEKPD-Sei-0665	Si021033m.g	K3Z3B5	LOC101783342
48		iEKPD-Sei-0206	Si005733m.g	K3XUX6	LOC101786584
49		iEKPD-Sei-0006	Si000125m.g	K3XE08	SETIT_000125mg
50		iEKPD-Sei-0164	Si004331m.g	K3XQZ2	SETIT_004331mg
51		iEKPD-Sei-0198	Si005183m.g	K3XTC7	SETIT_005183mg
52		iEKPD-Sei-0203	Si005722m.g	K3XUW5	SETIT_005722mg
53		iEKPD-Sei-0361	Si009672m.g	K3Y633	SETIT_009672mg
54		iEKPD-Sei-0417	Si012513m.g	K3YE52	SETIT_012513mg
55		iEKPD-Sei-0446	Si013330m.g	K3YGG2	SETIT_013330mg
56		iEKPD-Sei-0479	Si015231m.g	K3YLV5	SETIT_015231mg
57		iEKPD-Sei-0808	Si025087m.g	A0A0Q3SRP7	SETIT_025087mg
58		iEKPD-Sei-0896	Si027268m.g	K3ZL12	SETIT_027268mg
59		iEKPD-Sei-0979	Si028782m.g	K3ZQA2	SETIT_028782mg
60		iEKPD-Sei-1007	Si029054m.g	K3ZR24	SETIT_029054mg
61		iEKPD-Sei-1086	Si030660m.g	A0A0Q3VLM5	SETIT_0306602mg
62		iEKPD-Sei-1305	Si038884m.g	K4AJ20	SETIT_038884mg