※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sob-0001	SORBI_3001G002000	C5WRU5	SORBI_3001G002000
2		iEKPD-Sob-0012	SORBI_3001G039500	A0A1B6QH74	SORBI_3001G039500
3		iEKPD-Sob-0039	SORBI_3001G092500	C5X171	SORBI_3001G092500
4		iEKPD-Sob-0066	SORBI_3001G159400	A0A1B6QJ72	SORBI_3001G159400
5		iEKPD-Sob-0086	SORBI_3001G241200	A0A1B6QKP3	SORBI_3001G241200
6		iEKPD-Sob-0138	SORBI_3001G404700	A0A1B6QNU0	SORBI_3001G404700
7		iEKPD-Sob-0139	SORBI_3001G405000	A0A1B6QNU2	SORBI_3001G405000
8		iEKPD-Sob-0170	SORBI_3001G497300	C5WWZ5	SORBI_3001G497300
9		iEKPD-Sob-0188	SORBI_3002G005800	A0A1B6Q8M8	SORBI_3002G005800
10		iEKPD-Sob-0196	SORBI_3002G021900	A0A1W0W1W5	SORBI_3002G021900
11		iEKPD-Sob-0198	SORBI_3002G023000	A0A1B6Q8S6	SORBI_3002G023000
12		iEKPD-Sob-0239	SORBI_3002G133400	A0A1W0W3Q9	SORBI_3002G133400
13		iEKPD-Sob-0279	SORBI_3002G218200	A0A1W0W5G0	SORBI_3002G218200
14		iEKPD-Sob-0293	SORBI_3002G283300	C5X6Z5	SORBI_3002G283300
15		iEKPD-Sob-0303	SORBI_3002G300400	C5X8H9	SORBI_3002G300400
16		iEKPD-Sob-0347	SORBI_3002G375500	A0A1B6QFM3	SORBI_3002G375500
17		iEKPD-Sob-0352	SORBI_3002G383100	A0A1B6QFP2	SORBI_3002G383100
18		iEKPD-Sob-0353	SORBI_3002G386800	C5X381	SORBI_3002G386800
19		iEKPD-Sob-0378	SORBI_3003G024100	C5XL54	SORBI_3003G024100
20		iEKPD-Sob-0383	SORBI_3003G027500	C5XL91	SORBI_3003G027500
21		iEKPD-Sob-0430	SORBI_3003G103000	C5XEZ8	SORBI_3003G103000
22		iEKPD-Sob-0444	SORBI_3003G147200	A0A1B6Q3E1	SORBI_3003G147200
23		iEKPD-Sob-0473	SORBI_3003G224200	C5XR52	SORBI_3003G224200
24		iEKPD-Sob-0478	SORBI_3003G235000	C5XEK6	SORBI_3003G235000
25		iEKPD-Sob-0488	SORBI_3003G253600	C5XG37	SORBI_3003G253600
26		iEKPD-Sob-0498	SORBI_3003G265900	A0A1B6Q5I2	SORBI_3003G265900
27		iEKPD-Sob-0513	SORBI_3003G294000	A0A1W0VZG7	SORBI_3003G294000
28		iEKPD-Sob-0514	SORBI_3003G295200	C5XK33	SORBI_3003G295200
29		iEKPD-Sob-0549	SORBI_3003G385000	A0A1B6Q7H2	SORBI_3003G385000
30		iEKPD-Sob-0572	SORBI_3004G016800	C5XSY9	SORBI_3004G016800
31		iEKPD-Sob-0587	SORBI_3004G047300	C5XVD0	SORBI_3004G047300
32		iEKPD-Sob-0590	SORBI_3004G059000	C5XW65	SORBI_3004G059000
33		iEKPD-Sob-0605	SORBI_3004G094300	A0A1Z5RLP0	SORBI_3004G094300
34		iEKPD-Sob-0612	SORBI_3004G106400	C5XYZ6	SORBI_3004G106400
35		iEKPD-Sob-0622	SORBI_3004G163300	A0A194YR70	SORBI_3004G163300
36		iEKPD-Sob-0633	SORBI_3004G200400	C5XWH5	SORBI_3004G200400
37		iEKPD-Sob-0637	SORBI_3004G209900	A0A194YQU8	SORBI_3004G209900
38		iEKPD-Sob-0652	SORBI_3004G240800	C5XYV4	SORBI_3004G240800
39		iEKPD-Sob-0677	SORBI_3004G322600	A0A194YST5	SORBI_3004G322600
40		iEKPD-Sob-0715	SORBI_3005G046500	A0A1B6PQ54	SORBI_3005G046500
41		iEKPD-Sob-0785	SORBI_3005G203200	A0A1Z5RKF4	SORBI_3005G203200
42		iEKPD-Sob-0792	SORBI_3005G213200	C5Y7W7	SORBI_3005G213200
43		iEKPD-Sob-0859	SORBI_3006G208900	C5YFK8	SORBI_3006G208900
44		iEKPD-Sob-0860	SORBI_3006G210900	A0A1Z5RFU9	SORBI_3006G210900
45		iEKPD-Sob-0893	SORBI_3006G252700	A0A1B6PNU8	SORBI_3006G252700
46		iEKPD-Sob-0900	SORBI_3006G276100	C5YB12	SORBI_3006G276100
47		iEKPD-Sob-0903	SORBI_3007G002300	A0A1B6PEQ5	SORBI_3007G002300
48		iEKPD-Sob-0923	SORBI_3007G078300	A0A1B6PGA5	SORBI_3007G078300
49		iEKPD-Sob-0924	SORBI_3007G078500	C5YIX5	SORBI_3007G078500
50		iEKPD-Sob-0936	SORBI_3007G125900	C5YKV8	SORBI_3007G125900
51		iEKPD-Sob-0994	SORBI_3008G046800	C5YS95	SORBI_3008G046800
52		iEKPD-Sob-1753	SORBI_3008G053000	A0A1Z5R615	SORBI_3008G053000
53		iEKPD-Sob-1033	SORBI_3008G151100	A0A1Z5R6Z1	SORBI_3008G151100
54		iEKPD-Sob-1036	SORBI_3008G161000	A0A1B6PE21	SORBI_3008G161000
55		iEKPD-Sob-1080	SORBI_3009G047200	C5Z067	SORBI_3009G047200
56		iEKPD-Sob-1141	SORBI_3009G200800	C5Z1A7	SORBI_3009G200800
57		iEKPD-Sob-1157	SORBI_3009G242800	C5YW43	SORBI_3009G242800
58		iEKPD-Sob-1162	SORBI_3009G249400	A0A1B6PAF5	SORBI_3009G249400
59		iEKPD-Sob-1168	SORBI_3009G258000	A0A1Z5R5A4	SORBI_3009G258000
60		iEKPD-Sob-1192	SORBI_3010G063300	A0A1W0VRQ4	SORBI_3010G063300
61		iEKPD-Sob-1203	SORBI_3010G094900	A0A194YI63	SORBI_3010G094900
62		iEKPD-Sob-1208	SORBI_3010G120800	C5Z8Z1	SORBI_3010G120800
63		iEKPD-Sob-1239	SORBI_3010G200800	C5Z6K7	SORBI_3010G200800
64		iEKPD-Sob-1242	SORBI_3010G207400	C5Z6R6	SORBI_3010G207400