※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sus-0416	ENSSSCG00000032800.1	A0A286ZME3
2		iEKPD-Sus-0335	ENSSSCG00000023272.2	I3L9C8	ILK
3		iEKPD-Sus-0469	ENSSSCG00000040109.1	A0A287ACR4	LOC102164667
4		iEKPD-Sus-0375	ENSSSCG00000028036.2	I3LT36	MAP3K10
5		iEKPD-Sus-0449	ENSSSCG00000037531.1	A0A287B2Q3	MAP3K11
6		iEKPD-Sus-0005	ENSSSCG00000000275.3	I3L8B0	MAP3K12
7		iEKPD-Sus-0204	ENSSSCG00000011791.3	A0A287BBN8	MAP3K13
8		iEKPD-Sus-0272	ENSSSCG00000015960.3	F1S066	MAP3K20
9		iEKPD-Sus-0166	ENSSSCG00000010164.3	F1RGV0	MAP3K21
10		iEKPD-Sus-0033	ENSSSCG00000002329.3	A0A287A0S9	MAP3K9
11		iEKPD-Sus-0065	ENSSSCG00000004334.4	B0LXP5	TAK1b