※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-0225	ENSTGUG00000006958.1	H0Z9B6
2		iEKPD-Tag-0308	ENSTGUG00000010382.1	H0ZJE9
3		iEKPD-Tag-0311	ENSTGUG00000010396.1	H0ZJF5
4		iEKPD-Tag-0023	ENSTGUG00000000595.1	H0YQQ2	ILK
5		iEKPD-Tag-0498	ENSTGUG00000016337.1	H1A179	LOC100224427
6		iEKPD-Tag-0276	ENSTGUG00000008657.1	H0ZEB6	MAP3K20
7		iEKPD-Tag-0304	ENSTGUG00000010194.1	H0ZIV1	MAP3K21
8		iEKPD-Tag-0367	ENSTGUG00000012360.1	H0ZQ54	MAP3K7
9		iEKPD-Tag-0336	ENSTGUG00000011356.1	H0ZM86	MAP3K9