※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

  Reviewed (0)  or Unreviewed (9) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tar-0409	ENSTRUG00000012557.1	H2U4E0
2		iEKPD-Tar-0221	ENSTRUG00000006835.1	H2SWJ7	ilk
3		iEKPD-Tar-0352	ENSTRUG00000010691.1	H2TQL6	LOC101074511
4		iEKPD-Tar-0395	ENSTRUG00000012102.1	H2U116	MAP3K13
5		iEKPD-Tar-0577	ENSTRUG00000017637.1	H2V7M0	map3k20
6		iEKPD-Tar-0132	ENSTRUG00000004366.1	H2SDA2	MAP3K20 (1 of many)
7		iEKPD-Tar-0109	ENSTRUG00000003898.1	H2S9W5	MAP3K21
8		iEKPD-Tar-0187	ENSTRUG00000005867.1	H2SPG2	map3k7
9		iEKPD-Tar-0575	ENSTRUG00000017590.1	H2V793	tnni3k