Brassica oleracea      TKL/RAF


※ RAF family introduction

    RAF kinases are serine/threonine kinase and belong to TKL family. Sequence analysis of RAF kinase shows that three conserved domain is present in RAFs, known as CR1-3. CR1 contains two Ras binding domains (RBD and CRD), serine/threonine are rich in CR2 and CR3 contains a protein kinase catalytic domain. RAFs are key regulator involved in RAS-RAF-MEK-ERK signal transduction cascade, also known as MAPK cascade. RAS is activated by GTPase via a multistage process. Activate RAFs will subsequently lead to the activation of MEK1 and MEK2 and transduce the signal to downstream molecules (1).

Reference
1. Roskoski, R., Jr. (2010) RAF protein-serine/threonine kinases: structure and regulation. Biochem Biophys Res Commun, 399, 313-317. PMID: 20674547


There are 7 genes.  Reviewed (0 or Unreviewed (7

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Bro-0019
Bo00763s060
A0A0D2ZQY1
2
iEKPD-Bro-0063
Bo02299s010
A0A0D2ZW17
3
iEKPD-Bro-0160
Bo1g037080
A0A0D3A5P9
4
iEKPD-Bro-0243
Bo1g147810
A0A0D3AFA0
5
iEKPD-Bro-0324
Bo2g047680
A0A0D3AMQ8
6
iEKPD-Bro-0903
Bo4g154440
A0A0D3C1Q6
7
iEKPD-Bro-g009
Bo7g105230
A0A0D3DEM5