Chlorocebus sabaeus      TKL/RAF


※ RAF family introduction

    RAF kinases are serine/threonine kinase and belong to TKL family. Sequence analysis of RAF kinase shows that three conserved domain is present in RAFs, known as CR1-3. CR1 contains two Ras binding domains (RBD and CRD), serine/threonine are rich in CR2 and CR3 contains a protein kinase catalytic domain. RAFs are key regulator involved in RAS-RAF-MEK-ERK signal transduction cascade, also known as MAPK cascade. RAS is activated by GTPase via a multistage process. Activate RAFs will subsequently lead to the activation of MEK1 and MEK2 and transduce the signal to downstream molecules (1).

Reference
1. Roskoski, R., Jr. (2010) RAF protein-serine/threonine kinases: structure and regulation. Biochem Biophys Res Commun, 399, 313-317. PMID: 20674547


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Chs-g011
ENSCSAG00000008218.1
A0A0D9R789
2
iEKPD-Chs-0335
ENSCSAG00000013622.1
A0A0D9RME4
ARAF
3
iEKPD-Chs-0172
ENSCSAG00000007628.1
A0A0D9R5F5
KSR1
4
iEKPD-Chs-0045
ENSCSAG00000002318.1
A0A0D9S4D1
KSR2
5
iEKPD-Chs-0229
ENSCSAG00000009721.1
A0A0D9RB89
RAF1