※ RAF family introduction

    RAF kinases are serine/threonine kinase and belong to TKL family. Sequence analysis of RAF kinase shows that three conserved domain is present in RAFs, known as CR1-3. CR1 contains two Ras binding domains (RBD and CRD), serine/threonine are rich in CR2 and CR3 contains a protein kinase catalytic domain. RAFs are key regulator involved in RAS-RAF-MEK-ERK signal transduction cascade, also known as MAPK cascade. RAS is activated by GTPase via a multistage process. Activate RAFs will subsequently lead to the activation of MEK1 and MEK2 and transduce the signal to downstream molecules (1).

Reference
1. Roskoski, R., Jr. (2010) RAF protein-serine/threonine kinases: structure and regulation. Biochem Biophys Res Commun, 399, 313-317. PMID: 20674547

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Hea-0152	HannXRQ_Chr02g0037171	A0A251VDJ6	HannXRQ_Chr02g0037171
2		iEKPD-Hea-0197	HannXRQ_Chr02g0052761	A0A251VHJ4	HannXRQ_Chr02g0052761
3		iEKPD-Hea-0456	HannXRQ_Chr04g0103071	A0A251UWJ6	HannXRQ_Chr04g0103071
4		iEKPD-Hea-0548	HannXRQ_Chr05g0130281	A0A251ULC4	HannXRQ_Chr05g0130281
5		iEKPD-Hea-0575	HannXRQ_Chr05g0135441	A0A251UPS1	HannXRQ_Chr05g0135441
6		iEKPD-Hea-g038	HannXRQ_Chr06g0165311	A0A251UG81	HannXRQ_Chr06g0165311
7		iEKPD-Hea-1186	HannXRQ_Chr10g0292101	A0A251TIB5	HannXRQ_Chr10g0292101
8		iEKPD-Hea-1306	HannXRQ_Chr10g0315401	A0A251TPC1	HannXRQ_Chr10g0315401
9		iEKPD-Hea-1444	HannXRQ_Chr11g0338901	A0A251TAW1	HannXRQ_Chr11g0338901
10		iEKPD-Hea-1626	HannXRQ_Chr12g0368021	A0A251T1Y5	HannXRQ_Chr12g0368021
11		iEKPD-Hea-g026	HannXRQ_Chr13g0412331	A0A251SUI6	HannXRQ_Chr13g0412331
12		iEKPD-Hea-1813	HannXRQ_Chr13g0412721	A0A251SUA7	HannXRQ_Chr13g0412721
13		iEKPD-Hea-1911	HannXRQ_Chr14g0434061	A0A251SFH2	HannXRQ_Chr14g0434061
14		iEKPD-Hea-2296	HannXRQ_Chr16g0503891	A0A251RWK4	HannXRQ_Chr16g0503891