※ RAF family introduction

    RAF kinases are serine/threonine kinase and belong to TKL family. Sequence analysis of RAF kinase shows that three conserved domain is present in RAFs, known as CR1-3. CR1 contains two Ras binding domains (RBD and CRD), serine/threonine are rich in CR2 and CR3 contains a protein kinase catalytic domain. RAFs are key regulator involved in RAS-RAF-MEK-ERK signal transduction cascade, also known as MAPK cascade. RAS is activated by GTPase via a multistage process. Activate RAFs will subsequently lead to the activation of MEK1 and MEK2 and transduce the signal to downstream molecules (1).

Reference
1. Roskoski, R., Jr. (2010) RAF protein-serine/threonine kinases: structure and regulation. Biochem Biophys Res Commun, 399, 313-317. PMID: 20674547

  Reviewed (1)  or Unreviewed (4) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sus-0214	ENSSSCG00000012275.4	O19004	ARAF
2		iEKPD-Sus-0285	ENSSSCG00000016494.3	A0A286ZVY2	BRAF
3		iEKPD-Sus-0307	ENSSSCG00000017753.3	F1RJ53	KSR1
4		iEKPD-Sus-0159	ENSSSCG00000009855.3	F1RKG1	KSR2
5		iEKPD-Sus-0342	ENSSSCG00000024453.2	I3LAS8	RAF1