※ RAF family introduction

    RAF kinases are serine/threonine kinase and belong to TKL family. Sequence analysis of RAF kinase shows that three conserved domain is present in RAFs, known as CR1-3. CR1 contains two Ras binding domains (RBD and CRD), serine/threonine are rich in CR2 and CR3 contains a protein kinase catalytic domain. RAFs are key regulator involved in RAS-RAF-MEK-ERK signal transduction cascade, also known as MAPK cascade. RAS is activated by GTPase via a multistage process. Activate RAFs will subsequently lead to the activation of MEK1 and MEK2 and transduce the signal to downstream molecules (1).

Reference
1. Roskoski, R., Jr. (2010) RAF protein-serine/threonine kinases: structure and regulation. Biochem Biophys Res Commun, 399, 313-317. PMID: 20674547

  Reviewed (0)  or Unreviewed (7) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tra-1320	TRIAE_CS42_2DS_TGACv1_177198_AA0568750	A0A1D5UV17
2		iEKPD-Tra-2641	TRIAE_CS42_4DS_TGACv1_361162_AA1162310	A0A1D5Y5P4
3		iEKPD-Tra-3238	TRIAE_CS42_5DL_TGACv1_433778_AA1421870	A0A1D5ZP92
4		iEKPD-Tra-4319	TRIAE_CS42_7BS_TGACv1_591845_AA1923420	A0A1D6SE73
5		iEKPD-Tra-g028	TRIAE_CS42_1AL_TGACv1_004270_AA0052990	A0A096UJW3
6		iEKPD-Tra-g004	TRIAE_CS42_3AL_TGACv1_194276_AA0630100	A0A1D5V7E4
7		iEKPD-Tra-g029	TRIAE_CS42_6BS_TGACv1_514124_AA1655670	A0A1D6AYF3