Vitis vinifera      TKL/RAF


※ RAF family introduction

    RAF kinases are serine/threonine kinase and belong to TKL family. Sequence analysis of RAF kinase shows that three conserved domain is present in RAFs, known as CR1-3. CR1 contains two Ras binding domains (RBD and CRD), serine/threonine are rich in CR2 and CR3 contains a protein kinase catalytic domain. RAFs are key regulator involved in RAS-RAF-MEK-ERK signal transduction cascade, also known as MAPK cascade. RAS is activated by GTPase via a multistage process. Activate RAFs will subsequently lead to the activation of MEK1 and MEK2 and transduce the signal to downstream molecules (1).

Reference
1. Roskoski, R., Jr. (2010) RAF protein-serine/threonine kinases: structure and regulation. Biochem Biophys Res Commun, 399, 313-317. PMID: 20674547


There are 7 genes.  Reviewed (0 or Unreviewed (7

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Viv-0120
VIT_00s0936g00010
F6HJW3
VIT_00s0936g00010
2
iEKPD-Viv-0121
VIT_00s1002g00020
D7TGE6
VIT_00s1002g00020
3
iEKPD-Viv-0122
VIT_00s1190g00010
F6GZG6
VIT_00s1190g00010
4
iEKPD-Viv-0716
VIT_11s0016g01010
F6HGS9
VIT_11s0016g01010
5
iEKPD-Viv-0768
VIT_12s0028g01040
F6H575
VIT_12s0028g01040
6
iEKPD-Viv-1697
VIT_18s0001g01930
F6H0I6
VIT_18s0001g01930
7
iEKPD-Viv-1170
VIT_18s0001g02580
F6HJE4
VIT_18s0001g02580