※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Aim-0162	ENSAMEG00000005925.1	G1LH69
2		iEKPD-Aim-0335	ENSAMEG00000014318.1	G1M6Y2	ACVR1
3		iEKPD-Aim-0046	ENSAMEG00000001774.1	G1L4T7	ACVR1B
4		iEKPD-Aim-0336	ENSAMEG00000014338.1	G1M6Z7	ACVR1C
5		iEKPD-Aim-0312	ENSAMEG00000013434.1	G1M4A6	ACVR2A
6		iEKPD-Aim-0425	ENSAMEG00000017697.1	G1MH74	ACVR2B
7		iEKPD-Aim-0048	ENSAMEG00000001811.1	G1L4X5	ACVRL1
8		iEKPD-Aim-0289	ENSAMEG00000012496.1	G1M1F7	AMHR2
9		iEKPD-Aim-0234	ENSAMEG00000009972.1	G1LTU6	BMPR1A
10		iEKPD-Aim-0163	ENSAMEG00000005926.1	G1LH84	BMPR1B
11		iEKPD-Aim-0305	ENSAMEG00000013148.1	G1M3F0	BMPR2
12		iEKPD-Aim-0121	ENSAMEG00000004381.1	G1LCI9	TGFBR1