※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (11) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Anp-0210	ENSAPLG00000009253.1	U3INX3
2		iEKPD-Anp-0096	ENSAPLG00000004767.1	U3IAS2	ACVR1
3		iEKPD-Anp-0261	ENSAPLG00000010616.1	R0JN42	ACVR1B
4		iEKPD-Anp-0117	ENSAPLG00000005547.1	U3ICY1	ACVR1C
5		iEKPD-Anp-0280	ENSAPLG00000011198.1	U3IUS5	ACVR2A
6		iEKPD-Anp-0306	ENSAPLG00000012223.1	U3IXR1	ACVR2B
7		iEKPD-Anp-0353	ENSAPLG00000013998.1	U3J2X7	BMPR1A
8		iEKPD-Anp-0052	ENSAPLG00000003297.1	R0JKI9	BMPR1B
9		iEKPD-Anp-0186	ENSAPLG00000008092.1	U3IKP1	BMPR2
10		iEKPD-Anp-0237	ENSAPLG00000009967.1	U3IR17	TGFBR1
11		iEKPD-Anp-0304	ENSAPLG00000012100.1	R0LPX2	TGFBR2