※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (13) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Anc-0166	ENSACAG00000007562.3	H9GCW2	ACVR1
2		iEKPD-Anc-0416	ENSACAG00000016836.3	G1KT77	ACVR1B
3		iEKPD-Anc-0170	ENSACAG00000007686.3	H9GCZ4	ACVR1C
4		iEKPD-Anc-0081	ENSACAG00000003484.3	H9G7M4	ACVR2A
5		iEKPD-Anc-0211	ENSACAG00000009033.3	H9GET5	ACVR2B
6		iEKPD-Anc-0421	ENSACAG00000016876.3	G1KT96	ACVRL1
7		iEKPD-Anc-0020	ENSACAG00000000671.3	G1K8P3	AMHR2
8		iEKPD-Anc-0358	ENSACAG00000014543.3	H9GLF0	BMPR1A
9		iEKPD-Anc-0334	ENSACAG00000013701.3	G1KP73	BMPR1B
10		iEKPD-Anc-0107	ENSACAG00000004885.3	H9G9P4	BMPR2
11		iEKPD-Anc-0237	ENSACAG00000009909.3	G1KJI1	LOC100556560
12		iEKPD-Anc-0215	ENSACAG00000009195.3	G1KIM7	TGFBR1
13		iEKPD-Anc-0346	ENSACAG00000014301.3	G1KPQ7	TGFBR2