※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Caj-0327	ENSCJAG00000015359.1	F7B7W8	ACVR1
2		iEKPD-Caj-0384	ENSCJAG00000017891.2	F6U566	ACVR1B
3		iEKPD-Caj-0329	ENSCJAG00000015385.2	F6ZNW8	ACVR1C
4		iEKPD-Caj-0266	ENSCJAG00000012496.2	F7I856	ACVR2A
5		iEKPD-Caj-0212	ENSCJAG00000010067.2	F7CZG7	ACVR2B
6		iEKPD-Caj-0383	ENSCJAG00000017879.2	F6PVJ9	ACVRL1
7		iEKPD-Caj-0399	ENSCJAG00000018563.2	F7IKA7	AMHR2
8		iEKPD-Caj-0240	ENSCJAG00000011555.2	F6QTD3	BMPR1A
9		iEKPD-Caj-0149	ENSCJAG00000006930.2	F6RPX2	BMPR1B
10		iEKPD-Caj-0111	ENSCJAG00000005066.2	F7HI91	BMPR2
11		iEKPD-Caj-0233	ENSCJAG00000011244.2	F7H653	TGFBR1
12		iEKPD-Caj-0088	ENSCJAG00000004363.2	F6Z930	TGFBR2