※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Caf-0199	ENSCAFG00000009287.3	E2RKJ3	ACVR1
2		iEKPD-Caf-0167	ENSCAFG00000007357.4	F1PPK6	ACVR1B
3		iEKPD-Caf-0198	ENSCAFG00000009269.4	E2RLG0	ACVR1C
4		iEKPD-Caf-0119	ENSCAFG00000005507.3	F1PKQ5	ACVR2A
5		iEKPD-Caf-0104	ENSCAFG00000005035.3	F1PGW4	ACVR2B
6		iEKPD-Caf-0449	ENSCAFG00000025220.2	E2R174	ACVRL1
7		iEKPD-Caf-0155	ENSCAFG00000006934.3	E2RI46	AMHR2
8		iEKPD-Caf-0347	ENSCAFG00000016077.3	E2QW66	BMPR1A
9		iEKPD-Caf-0218	ENSCAFG00000010107.3	E2RA74	BMPR1B
10		iEKPD-Caf-0444	ENSCAFG00000023687.2	F1PCC1	BMPR2
11		iEKPD-Caf-0056	ENSCAFG00000002528.4	F1PS63	TGFBR1
12		iEKPD-Caf-0118	ENSCAFG00000005449.3	F1PNA9	TGFBR2