※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cas-0114	ENSTSYG00000005098.2	A0A1U7T2P7	ACVR1
2		iEKPD-Cas-0228	ENSTSYG00000010146.2	A0A1U7U627	ACVR1B
3		iEKPD-Cas-0166	ENSTSYG00000007300.2	A0A1U7TBG0	ACVR1C
4		iEKPD-Cas-0165	ENSTSYG00000007212.2	A0A1U7TWM1	ACVR2A
5		iEKPD-Cas-0299	ENSTSYG00000013516.2	A0A1U7TC86	ACVR2B
6		iEKPD-Cas-0024	ENSTSYG00000001098.2	A0A1U7U612	ACVRL1
7		iEKPD-Cas-0026	ENSTSYG00000001128.2	A0A1U7TF85	AMHR2
8		iEKPD-Cas-0187	ENSTSYG00000008054.2	A0A1U7TE33	BMPR1A
9		iEKPD-Cas-0063	ENSTSYG00000002551.2	A0A1U7TES7	BMPR1B
10		iEKPD-Cas-0084	ENSTSYG00000003502.2	A0A1U7TZX1	BMPR2
11		iEKPD-Cas-0183	ENSTSYG00000007832.2	A0A1U7TAB6	TGFBR1
12		iEKPD-Cas-0044	ENSTSYG00000001953.2	A0A1U7TM67	TGFBR2