※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Dio-0180	ENSDORG00000008630.2
2		iEKPD-Dio-0307	ENSDORG00000013457.2	A0A1S3GB35	Acvr1
3		iEKPD-Dio-0379	ENSDORG00000023410.1	A0A1S3FCC3	Acvr1b
4		iEKPD-Dio-0216	ENSDORG00000010112.2	A0A1S3G4B1	Acvr1c
5		iEKPD-Dio-0324	ENSDORG00000014448.2	A0A1S3GB61	Acvr2a
6		iEKPD-Dio-0366	ENSDORG00000016137.2	A0A1S3FEB3	Acvrl1
7		iEKPD-Dio-0233	ENSDORG00000010718.2	A0A1S3GI74	Amhr2
8		iEKPD-Dio-0204	ENSDORG00000009762.2	A0A1S3GFB1	Bmpr1a
9		iEKPD-Dio-0005	ENSDORG00000000215.2	A0A1S3GAY2	Bmpr1b
10		iEKPD-Dio-0190	ENSDORG00000009209.2	A0A1S3F4A4	Bmpr2
11		iEKPD-Dio-0111	ENSDORG00000005067.2	A0A1S3FQQ6	Tgfbr1
12		iEKPD-Dio-0348	ENSDORG00000015040.2	A0A1S3G6P6	Tgfbr2