※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Drm-0043	FBgn0011300	A1Z7L8	babo
2		iEKPD-Drm-0017	FBgn0003169	A0A0B4KG59	put
3		iEKPD-Drm-0019	FBgn0003317	A0A0B4K7J3	sax
4		iEKPD-Drm-0022	FBgn0003716	Q9VMT1	tkv
5		iEKPD-Drm-0078	FBgn0024179	M9PE88	wit