※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Eqc-0299	ENSECAG00000018902.1	F7B4G7	ACVR1
2		iEKPD-Eqc-0162	ENSECAG00000011686.1	F6UAD3	ACVR1B
3		iEKPD-Eqc-0317	ENSECAG00000019682.1	F7CLA3	ACVR1C
4		iEKPD-Eqc-0004	ENSECAG00000000138.1	F7CD19	ACVR2A
5		iEKPD-Eqc-0314	ENSECAG00000019616.1	F7DXK7	ACVR2B
6		iEKPD-Eqc-0101	ENSECAG00000009133.1	F6YCL6	ACVRL1
7		iEKPD-Eqc-0332	ENSECAG00000020247.1	F7CE75	AMHR2
8		iEKPD-Eqc-0339	ENSECAG00000020461.1	F6UG39	BMPR1A
9		iEKPD-Eqc-0174	ENSECAG00000012140.1	F6SYZ2	BMPR1B
10		iEKPD-Eqc-0451	ENSECAG00000025141.1	F6SUZ9	BMPR2
11		iEKPD-Eqc-0036	ENSECAG00000004757.1	F7DAS1	TGFBR1
12		iEKPD-Eqc-0236	ENSECAG00000015269.1	F6UZ08	TGFBR2