※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ere-0307	ENSEEUG00000013057.1
2		iEKPD-Ere-0038	ENSEEUG00000001638.1	A0A1S2ZTK9	ACVR1
3		iEKPD-Ere-0288	ENSEEUG00000012570.1	A0A1S2ZTL9	ACVR1C
4		iEKPD-Ere-0028	ENSEEUG00000001195.1	A0A1S2ZNW0	ACVR2A
5		iEKPD-Ere-0089	ENSEEUG00000003992.1	A0A1S2ZCI2	ACVR2B
6		iEKPD-Ere-0296	ENSEEUG00000012833.1	A0A1S3W596	ACVRL1
7		iEKPD-Ere-0201	ENSEEUG00000008983.1	A0A1S3W5A2	AMHR2
8		iEKPD-Ere-0285	ENSEEUG00000012417.1	A0A1S3A6P8	BMPR1A
9		iEKPD-Ere-0044	ENSEEUG00000002225.1	A0A1S2ZU53	BMPR1B
10		iEKPD-Ere-0149	ENSEEUG00000006744.1	A0A1S3W828	BMPR2
11		iEKPD-Ere-0308	ENSEEUG00000013092.1	A0A1S2ZU81	LOC103114843
12		iEKPD-Ere-0198	ENSEEUG00000008867.1	A0A1S2ZBR2	TGFBR2