※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Fec-0152	ENSFCAG00000008054.4	A0A2I2U1C7	ACVR1
2		iEKPD-Fec-0372	ENSFCAG00000026263.2	M3X6B7	ACVR1B
3		iEKPD-Fec-0214	ENSFCAG00000011271.4	M3WES8	ACVR1C
4		iEKPD-Fec-0341	ENSFCAG00000023845.2	M3X9E4	ACVR2A
5		iEKPD-Fec-0063	ENSFCAG00000003157.4	M3VZT9	ACVR2B
6		iEKPD-Fec-0005	ENSFCAG00000000265.3	M3VUE2	ACVRL1
7		iEKPD-Fec-0120	ENSFCAG00000005894.3	M3W4X5	AMHR2
8		iEKPD-Fec-0392	ENSFCAG00000027895.2	M3XCQ9	BMPR1A
9		iEKPD-Fec-0318	ENSFCAG00000022227.2	A0A2I2V488	BMPR1B
10		iEKPD-Fec-0264	ENSFCAG00000014094.4	A0A2I2U8X3	BMPR2
11		iEKPD-Fec-0385	ENSFCAG00000027261.2	M3XFA5	TGFBR1
12		iEKPD-Fec-0092	ENSFCAG00000004384.4	M3W233	TGFBR2