※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Fia-0093	ENSFALG00000003085.1	U3JKB5	ACVR1
2		iEKPD-Fia-0004	ENSFALG00000000096.1	U3JBE7	ACVR1B
3		iEKPD-Fia-0091	ENSFALG00000003064.1	U3JK92	ACVR1C
4		iEKPD-Fia-0411	ENSFALG00000013851.1	U3KHF5	ACVR2A
5		iEKPD-Fia-0212	ENSFALG00000006801.1	U3JWE6	ACVR2B
6		iEKPD-Fia-0003	ENSFALG00000000094.1	U3JBE5	ACVRL1
7		iEKPD-Fia-0206	ENSFALG00000006680.1	U3JW25	BMPR1A
8		iEKPD-Fia-0190	ENSFALG00000006113.1	U3JUC2	BMPR1B
9		iEKPD-Fia-0131	ENSFALG00000004047.1	U3JN66	BMPR2
10		iEKPD-Fia-0399	ENSFALG00000013526.1	U3KGG3	LOC101808986
11		iEKPD-Fia-0390	ENSFALG00000013285.1	U3KFR0	TGFBR1
12		iEKPD-Fia-0284	ENSFALG00000009162.1	U3K3F2	TGFBR2