※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Fud-0214	ENSFDAG00000011254.1	A0A091ERD2	H920_00273
2		iEKPD-Fud-0014	ENSFDAG00000001117.1	A0A091DUB5	H920_03922
3		iEKPD-Fud-0334	ENSFDAG00000015595.1	A0A091EF34	H920_04642
4		iEKPD-Fud-0308	ENSFDAG00000014556.1	A0A091E8E3	H920_07172
5		iEKPD-Fud-0062	ENSFDAG00000005699.1	A0A091DK15	H920_07173
6		iEKPD-Fud-0247	ENSFDAG00000012384.1	A0A091D898	H920_11315
7		iEKPD-Fud-0277	ENSFDAG00000013183.1	A0A091D6I9	H920_11932
8		iEKPD-Fud-0030	ENSFDAG00000003167.1	A0A091CWZ8	H920_16111
9		iEKPD-Fud-0103	ENSFDAG00000007195.1	A0A091DHY8	H920_16112
10		iEKPD-Fud-0023	ENSFDAG00000002348.1	A0A091DER9	H920_17324
11		iEKPD-Fud-0001	ENSFDAG00000000069.1	A0A091CME8	H920_19540
12		iEKPD-Fud-0116	ENSFDAG00000007752.1	A0A091CLT7	H920_20295