※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (3)  or Unreviewed (9) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Gag-0369	ENSGALG00000037301.2	Q90ZK6	ACVR1
2		iEKPD-Gag-0204	ENSGALG00000012444.6	Q90669	ACVR2A
3		iEKPD-Gag-0185	ENSGALG00000011442.5	Q90999	TGFBR2
4		iEKPD-Gag-0304	ENSGALG00000029599.1	A0A1D5PT02	ACVR1B
5		iEKPD-Gag-0406	ENSGALG00000041257.1	A0A1D5P214	ACVR1C
6		iEKPD-Gag-0087	ENSGALG00000006158.5	F1NCI7	ACVR2B
7		iEKPD-Gag-0353	ENSGALG00000035635.1	A0A1D5P3Z7	ACVRL1
8		iEKPD-Gag-0029	ENSGALG00000002003.4	F1P3H0	BMPR1A
9		iEKPD-Gag-0200	ENSGALG00000012216.5	F1NTD3	BMPR1B
10		iEKPD-Gag-0127	ENSGALG00000008459.4	F6RIN4	BMPR2
11		iEKPD-Gag-0338	ENSGALG00000033179.2	Q06900	ChALK5
12		iEKPD-Gag-0198	ENSGALG00000012055.6	A0A1L1RJI3	Gga.10225