※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Gog-0066	ENSGGOG00000002934.3	A0A2I2Z234	ACVR1
2		iEKPD-Gog-0138	ENSGGOG00000006405.3	A0A2I2Y6J8	ACVR1B
3		iEKPD-Gog-0468	ENSGGOG00000039092.1	A0A2I2YVY6	ACVR1C
4		iEKPD-Gog-0379	ENSGGOG00000015713.3	G3RI43	ACVR2A
5		iEKPD-Gog-0042	ENSGGOG00000001827.3	G3SJA5	ACVR2B
6		iEKPD-Gog-0148	ENSGGOG00000006661.3	G3QUV9	ACVRL1
7		iEKPD-Gog-0294	ENSGGOG00000012599.3	G3RA34	AMHR2
8		iEKPD-Gog-0086	ENSGGOG00000003720.3	G3QMC3	BMPR1A
9		iEKPD-Gog-0281	ENSGGOG00000012093.4	G3R8S9	BMPR1B
10		iEKPD-Gog-0246	ENSGGOG00000010989.3	A0A2I2YY32	BMPR2
11		iEKPD-Gog-0084	ENSGGOG00000003634.3	A0A2I2ZVD2	TGFBR1
12		iEKPD-Gog-0410	ENSGGOG00000016911.3	G3RL67	TGFBR2