※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ict-0103	ENSSTOG00000004704.3	I3M4Q3	ACVR1
2		iEKPD-Ict-0017	ENSSTOG00000000480.3	I3LWQ4	ACVR1B
3		iEKPD-Ict-0189	ENSSTOG00000009159.3	A0A287DF70	ACVR1C
4		iEKPD-Ict-0406	ENSSTOG00000025105.2	I3MXE2	ACVR2A
5		iEKPD-Ict-0312	ENSSTOG00000014862.3	I3MNP8	ACVR2B
6		iEKPD-Ict-0016	ENSSTOG00000000477.3	I3LWQ1	ACVRL1
7		iEKPD-Ict-0085	ENSSTOG00000003607.3	I3M2K8	AMHR2
8		iEKPD-Ict-0334	ENSSTOG00000015838.3	I3MQG4	BMPR1A
9		iEKPD-Ict-0320	ENSSTOG00000015189.3	I3MPB5	BMPR1B
10		iEKPD-Ict-0058	ENSSTOG00000002359.3	I3M095	BMPR2
11		iEKPD-Ict-0287	ENSSTOG00000013570.3	I3ML93	TGFBR1
12		iEKPD-Ict-0345	ENSSTOG00000019376.2	A0A287CU99	TGFBR2