※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Loa-0145	ENSLAFG00000006865.2	G3TUY1	ACVR1
2		iEKPD-Loa-0064	ENSLAFG00000003306.3	G3UDV2	ACVR1B
3		iEKPD-Loa-0407	ENSLAFG00000022543.2	G3TQF4	ACVR1C
4		iEKPD-Loa-0054	ENSLAFG00000002628.4	G3SQU9	ACVR2A
5		iEKPD-Loa-0028	ENSLAFG00000001488.3	G3UH55	ACVR2B
6		iEKPD-Loa-0170	ENSLAFG00000008019.3	G3T112	ACVRL1
7		iEKPD-Loa-0374	ENSLAFG00000018046.3	G3TK14	AMHR2
8		iEKPD-Loa-0121	ENSLAFG00000005832.3	G3SWZ5	BMPR1A
9		iEKPD-Loa-0224	ENSLAFG00000010753.3	G3T672	BMPR1B
10		iEKPD-Loa-0311	ENSLAFG00000015201.4	G3TEP1	BMPR2
11		iEKPD-Loa-0181	ENSLAFG00000008572.3	G3U5X5	TGFBR1
12		iEKPD-Loa-0070	ENSLAFG00000003785.3	G3ST25	TGFBR2