※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Maf-0346	ENSMFAG00000040345.1
2		iEKPD-Maf-0390	ENSMFAG00000042305.1	G7PKM2	ACVR1
3		iEKPD-Maf-0086	ENSMFAG00000003464.1	G7PKJ4	ACVR2A
4		iEKPD-Maf-0274	ENSMFAG00000037039.1	G7P5Y0	BMPR1B
5		iEKPD-Maf-0331	ENSMFAG00000039766.1	G7PIB8	EGM_03248
6		iEKPD-Maf-0180	ENSMFAG00000031949.1	G7PIB9	EGM_03249
7		iEKPD-Maf-0354	ENSMFAG00000040829.1	G7PHV1	EGM_03297
8		iEKPD-Maf-0387	ENSMFAG00000042281.1	G7PKM1	EGM_03980
9		iEKPD-Maf-0182	ENSMFAG00000032075.1	G7PL79	EGM_04222
10		iEKPD-Maf-0448	ENSMFAG00000044981.1	G7PRU8	EGM_06805
11		iEKPD-Maf-0362	ENSMFAG00000041141.1	G7NYK2	EGM_10786
12		iEKPD-Maf-0099	ENSMFAG00000003965.1	G7NYB0	EGM_11168