※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (13) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mam-0443	ENSMMUG00000031530.2	F6WU70
2		iEKPD-Mam-0316	ENSMMUG00000018497.3	F7A9J8	ACVR1
3		iEKPD-Mam-0095	ENSMMUG00000006200.3	F7HNS7	ACVR1B
4		iEKPD-Mam-0054	ENSMMUG00000003707.3	F6S9J1	ACVR1C
5		iEKPD-Mam-0001	ENSMMUG00000000042.3	F7HPH2	ACVR2A
6		iEKPD-Mam-0328	ENSMMUG00000018790.3	A0A1D5R6G4	ACVR2B
7		iEKPD-Mam-0072	ENSMMUG00000004982.3	F7HG73	ACVRL1
8		iEKPD-Mam-0354	ENSMMUG00000020037.3	F7GDJ0	AMHR2
9		iEKPD-Mam-0195	ENSMMUG00000011852.2	F7H4T8	BMPR1A
10		iEKPD-Mam-0105	ENSMMUG00000006702.3	F7HJS7	BMPR1B
11		iEKPD-Mam-0151	ENSMMUG00000009009.3	F7H249	BMPR2
12		iEKPD-Mam-0016	ENSMMUG00000001304.3	A0A1D5QUK7	TGFBR1
13		iEKPD-Mam-0161	ENSMMUG00000010031.3	F6Q1B1	TGFBR2