※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Meg-0324	ENSMGAG00000012891.1	G1NJR2	ACVR1
2		iEKPD-Meg-0323	ENSMGAG00000012880.1	G1NJQ3	ACVR1C
3		iEKPD-Meg-0317	ENSMGAG00000012656.2	G1NJ60	ACVR2A
4		iEKPD-Meg-0107	ENSMGAG00000004400.2	G1MZ11	ACVR2B
5		iEKPD-Meg-0229	ENSMGAG00000009120.2	H9H1J4	ACVRL1
6		iEKPD-Meg-0046	ENSMGAG00000002464.2	G3UPV1	BMPR1A
7		iEKPD-Meg-0273	ENSMGAG00000011094.2	G3USG9	BMPR1B
8		iEKPD-Meg-0210	ENSMGAG00000008156.2	G1N7Y4	BMPR2
9		iEKPD-Meg-0308	ENSMGAG00000012177.1	G1NHW0	LOC100549829
10		iEKPD-Meg-0034	ENSMGAG00000002050.1	G1MT75	TGFBR1
11		iEKPD-Meg-0275	ENSMGAG00000011137.2	G1NF73	TGFBR2