※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mod-0295	ENSMODG00000014248.2	F6Y1R7
2		iEKPD-Mod-0457	ENSMODG00000027777.1	K7E2Q7
3		iEKPD-Mod-0085	ENSMODG00000004431.2	F6SCC5	ACVR1
4		iEKPD-Mod-0084	ENSMODG00000004411.3	F6SV50	ACVR1C
5		iEKPD-Mod-0065	ENSMODG00000003295.3	F7EG01	ACVR2A
6		iEKPD-Mod-0175	ENSMODG00000008889.2	F7BRY9	ACVR2B
7		iEKPD-Mod-0236	ENSMODG00000011158.3	F7AN33	BMPR1A
8		iEKPD-Mod-0404	ENSMODG00000019262.3	F6Q8L1	BMPR1B
9		iEKPD-Mod-0343	ENSMODG00000016287.4	F7AU53	BMPR2
10		iEKPD-Mod-0263	ENSMODG00000012679.3	F6VGC3	TGFBR1
11		iEKPD-Mod-0309	ENSMODG00000015155.3	F7CFN3	TGFBR2