※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (12)  or Unreviewed (0) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mum-0200	ENSMUSG00000026836.15	P37172	Acvr1; Acvrlk2; Tgfb1
2		iEKPD-Mum-0004	ENSMUSG00000000532.10	Q61271	Acvr1b; Alk4
3		iEKPD-Mum-0199	ENSMUSG00000026834.13	Q8K348	Acvr1c; Alk7
4		iEKPD-Mum-0395	ENSMUSG00000052155.5	P27038	Acvr2a; Acvr2
5		iEKPD-Mum-0426	ENSMUSG00000061393.14	P27040	Acvr2b
6		iEKPD-Mum-0003	ENSMUSG00000000530.16	Q61288	Acvrl1; Acvrlk1; Alk-1
7		iEKPD-Mum-0136	ENSMUSG00000023047.10	Q8K592	Amhr2
8		iEKPD-Mum-0117	ENSMUSG00000021796.15	P36895	Bmpr1a; Acvrlk3; Bmpr
9		iEKPD-Mum-0396	ENSMUSG00000052430.15	P36898	Bmpr1b; Acvrlk6
10		iEKPD-Mum-0443	ENSMUSG00000067336.6	O35607	Bmpr2
11		iEKPD-Mum-0049	ENSMUSG00000007613.15	Q64729	Tgfbr1
12		iEKPD-Mum-0291	ENSMUSG00000032440.13	Q62312	Tgfbr2