※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Muf-0017	ENSMPUG00000000465.1	M3XN09	ACVR1
2		iEKPD-Muf-0187	ENSMPUG00000007757.1	M3Y8P4	ACVR1B
3		iEKPD-Muf-0016	ENSMPUG00000000461.1	M3XN06	ACVR1C
4		iEKPD-Muf-0094	ENSMPUG00000003611.1	M3XWY2	ACVR2A
5		iEKPD-Muf-0068	ENSMPUG00000002620.1	M3XU40	ACVR2B
6		iEKPD-Muf-0190	ENSMPUG00000007859.1	M3Y8Z4	ACVRL1
7		iEKPD-Muf-0150	ENSMPUG00000006005.1	M3Y3Q2	AMHR2
8		iEKPD-Muf-0221	ENSMPUG00000008847.1	M3YBS0	BMPR1A
9		iEKPD-Muf-0053	ENSMPUG00000002097.1	M3XSM6	BMPR1B
10		iEKPD-Muf-0011	ENSMPUG00000000354.1	M3XMQ1	BMPR2
11		iEKPD-Muf-0163	ENSMPUG00000006676.1	M3Y5M1	TGFBR1
12		iEKPD-Muf-0292	ENSMPUG00000011952.1	M3YKK3	TGFBR2