※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Myl-0234	ENSMLUG00000010119.2	G1PFA1	ACVR1
2		iEKPD-Myl-0101	ENSMLUG00000004487.1	G1P2J4	ACVR1B
3		iEKPD-Myl-0053	ENSMLUG00000002433.2	G1NXU6	ACVR1C
4		iEKPD-Myl-0147	ENSMLUG00000006484.2	G1P750	ACVR2A
5		iEKPD-Myl-0424	ENSMLUG00000022627.1	G1QDQ5	ACVR2B
6		iEKPD-Myl-0027	ENSMLUG00000001422.2	G1NVK2	ACVRL1
7		iEKPD-Myl-0405	ENSMLUG00000017305.2	G1PWK0	AMHR2
8		iEKPD-Myl-0228	ENSMLUG00000009947.2	G1PEW7	BMPR1A
9		iEKPD-Myl-0210	ENSMLUG00000009090.2	G1PCW7	BMPR1B
10		iEKPD-Myl-0342	ENSMLUG00000014783.2	G1PQS5	BMPR2
11		iEKPD-Myl-0352	ENSMLUG00000015003.2	G1PRA8	TGFBR1
12		iEKPD-Myl-0413	ENSMLUG00000017507.2	G1PX13	TGFBR2