※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Nol-0028	ENSNLEG00000000837.2	G1QJA7	ACVR1
2		iEKPD-Nol-0432	ENSNLEG00000017765.3	G1S7T1	ACVR1B
3		iEKPD-Nol-0027	ENSNLEG00000000817.2	G1QJ68	ACVR1C
4		iEKPD-Nol-0220	ENSNLEG00000009051.2	G1RCV0	ACVR2A
5		iEKPD-Nol-0143	ENSNLEG00000005401.2	G1R033	ACVR2B
6		iEKPD-Nol-0433	ENSNLEG00000017766.2	G1S7T4	ACVRL1
7		iEKPD-Nol-0430	ENSNLEG00000017698.3	G1S7I9	AMHR2
8		iEKPD-Nol-0069	ENSNLEG00000002425.3	A0A2I3FXJ3	BMPR1A
9		iEKPD-Nol-0335	ENSNLEG00000014109.2	G1RVC0	BMPR1B
10		iEKPD-Nol-0177	ENSNLEG00000007004.3	A0A2I3HEB5	BMPR2
11		iEKPD-Nol-0414	ENSNLEG00000017038.3	A0A2I3HC40	TGFBR1
12		iEKPD-Nol-0113	ENSNLEG00000004162.2	G1QVR5	TGFBR2