※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ora-0087	ENSOANG00000003970.2	F6S9E3
2		iEKPD-Ora-0121	ENSOANG00000005650.1	F7AG52
3		iEKPD-Ora-0284	ENSOANG00000011923.1	F6R6K5
4		iEKPD-Ora-0465	ENSOANG00000030744.1	K7ECP7
5		iEKPD-Ora-0133	ENSOANG00000006134.2	F6VZX5	ACVR1
6		iEKPD-Ora-0132	ENSOANG00000006133.3	F6W004	ACVR1C
7		iEKPD-Ora-0186	ENSOANG00000008384.1	F6XMR2	ACVR2A
8		iEKPD-Ora-0203	ENSOANG00000008907.2	F7EDR2	BMPR1A
9		iEKPD-Ora-0312	ENSOANG00000012804.3	F7A5W4	BMPR1B
10		iEKPD-Ora-0296	ENSOANG00000012302.3	F7DKT4	BMPR2
11		iEKPD-Ora-0358	ENSOANG00000014872.3	F6X0S8	TGFBR1
12		iEKPD-Ora-0250	ENSOANG00000010530.2	F6YQ99	TGFBR2