※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (11) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Orc-0045	ENSOCUG00000002439.3	G1SHK1	ACVR1
2		iEKPD-Orc-0381	ENSOCUG00000017934.3	G1TES4	ACVR1B
3		iEKPD-Orc-0191	ENSOCUG00000009208.3	G1SWR9	ACVR1C
4		iEKPD-Orc-0340	ENSOCUG00000016398.3	G1TBJ7	ACVR2A
5		iEKPD-Orc-0395	ENSOCUG00000022530.2	G1TG64	ACVRL1
6		iEKPD-Orc-0083	ENSOCUG00000004151.3	G1TZ65	AMHR2
7		iEKPD-Orc-0355	ENSOCUG00000016925.3	G1TCM6	BMPR1A
8		iEKPD-Orc-0316	ENSOCUG00000015048.3	G1T8L9	BMPR1B
9		iEKPD-Orc-0035	ENSOCUG00000001971.3	G1SGJ0	BMPR2
10		iEKPD-Orc-0337	ENSOCUG00000016292.3	G1TBB8	TGFBR1
11		iEKPD-Orc-0335	ENSOCUG00000015963.3	G1TAL4	TGFBR2