※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Otg-0276	ENSOGAG00000011662.2	H0X5A0	ACVR1
2		iEKPD-Otg-0442	ENSOGAG00000029484.1	H0XRV7	ACVR1B
3		iEKPD-Otg-0281	ENSOGAG00000011965.2	H0X5W2	ACVR1C
4		iEKPD-Otg-0089	ENSOGAG00000004021.2	H0WNZ5	ACVR2A
5		iEKPD-Otg-0457	ENSOGAG00000032563.1	H0XRP7	ACVR2B
6		iEKPD-Otg-0091	ENSOGAG00000004094.2	H0WP57	ACVRL1
7		iEKPD-Otg-0434	ENSOGAG00000028440.1	H0XL93	AMHR2
8		iEKPD-Otg-0255	ENSOGAG00000010762.2	H0X3D9	BMPR1A
9		iEKPD-Otg-0068	ENSOGAG00000003063.2	H0WM21	BMPR1B
10		iEKPD-Otg-0169	ENSOGAG00000007765.2	H0WX01	BMPR2
11		iEKPD-Otg-0094	ENSOGAG00000004163.2	H0WPB6	TGFBR1
12		iEKPD-Otg-0002	ENSOGAG00000000125.2	H0WFS7	TGFBR2